Analytical and clinical validation of a circulating tumor DNA–based assay for multicancer early detection

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  • Create Date July 16, 2024
  • Last Updated July 16, 2024

Event:

2024 ASCO Annual Meeting - 03 June 2024;

Authors:

  • Le Son Tran;
  • Luu Hong Dang Nguyen;
  • Hanh Thi-Hue Nguyen;
  • Duy Sinh Nguyen;
  • Hung Sang Tang;
  • Hoa Giang;
  • Hoai-Nghia Nguyen;
  • Minh-Duy Phan;

Organization:

  • Gene Solutions, Ho Chi Minh City, Viet Nam;
  • Medical Genetics Institute, Ho Chi Minh City, Viet Nam;

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Real-world example from SPOT-MAS test results(7)​

“I had no personal or family history of cancer, but I decided to take the SPOT-MAS test. It detected ctDNA signals that pointed to possible tumors in my stomach and lung. I then underwent a gastroscopy and biopsy, which confirmed poorly differentiated signet ring cell adenocarcinoma in my stomach. I had a total gastrectomy with D2 lymph node dissection, and the post-surgery analysis showed that the cancer had already spread to my lymph nodes.

This experience made me realize how silent stomach cancer can be—and how critical early detection with SPOT-MAS truly is.”
Test taker with positive result
Test taker with positive resultLim
“My mother passed away from stage IV ovarian cancer. Since there’s no regular screening available for this type of cancer, it was only discovered when it was already too late. After that, I lived with constant fear and anxiety — wondering if I might have cancer too. That’s why I decided to take the SPOT-MAS test.

When I received a negative result, I felt an overwhelming sense of relief and joy. I know I can’t control everything, but I can take action. From now on, I plan to do annual screenings. If anything ever appears, I want to catch it early — when it’s still treatable.”
Test taker with negative result
Test taker with negative resultJane
Disclaimer: Names and images have been changed to protect the privacy of individuals. The stories are based on real SPOT-MAS test results.

(7) Luu Hong Dang Nguyen et al. 2024. A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study. Future Science OA, 10 (1).

SPOT-MAS Videos

Test Process

01

Request the test

Request the test through your primary care doctor. A prescription and 10ml blood collection are required.

02

Sequencing of cfDNA

Your extracted DNA from the plasma will be sequenced by Next–generation ctDNA technology to analyze multi–feature of DNA.

03

Returning results

Receive your ctDNA signal analysis results after 20 working days from the time sample is received at Gene Solutions Genomics Singapore laboratory.

SPOT-MAS video