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Pioneering a Tumor-Specific Methylation Atlas (TSMA) to Identify Tissue of Origin (TOO) in Multi-Cancer Early Detection

Cell free DNA (cfDNA)-based assays hold great potential in detecting early cancer signals. However, predicting the tissue-of-origin for multiple cancer types at an early stage remains challenging due to the low abundance of tumor- derived cfDNA and the confounding presence of various DNA components released from non- tumor sources.

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