Colorectal cancer is the third leading cause of cancer-related deaths worldwide, claiming over 900,000 lives annually (1). While early detection has resulted in a 91% survival rate (2), barriers to access and compliance in certain regions, particularly in Asian countries, result in many cases being diagnosed at late stages (3, 4).
In this video, we present a case study where the SPOT-MAS Test provided a non-invasive screening option for an 80-year-old female patient (5). The ctDNA signal from the test indicated potential tumors in the colorectal region, prompting a colonoscopy. Findings included a precancerous polyp and a tumor, both of which were surgically removed.
This case demonstrates how advanced tools like SPOT-MAS enable elderly individuals over 75 years old which are not typically recommended for invasive cancer screening methods such as colonoscopy.
References:
(1) GLOBOCAN 2022
(2) American Cancer Society’s (ACS) publication, Cancer Facts & Figures 2022 and Cancer Facts & Figures 2021; the ACS website; and the International Agency for Cancer Research website
(3) Veettil, S. K., Lim, K. G., Chaiyakunapruk, N., Ching, S. M., & Hassan, M. R. A. (2016). Colorectal cancer in Malaysia: Its burden and implications for a multiethnic country. Asian Journal of Surgery, 40(6), 481–489. https://doi.org/10.1016/j.asjsur.2016.07.005
(4) Li, D. (2018). Recent advances in colorectal cancer screening. Chronic Diseases and Translational Medicine, 4(3), 139–147. https://doi.org/10.1016/j.cdtm.2018.08.004
(5) Luu Hong Dang Nguyen et al. 2024. A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study. Future Science OA, 10(1). https://doi.org/10.1080/20565623.2024.2395244
